Ro 08-2750

CAS No. 37854-59-4

Ro 08-2750( —— )

Catalog No. M26808 CAS No. 37854-59-4

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 08-2750
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM.
  • Description
    Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA.(In Vitro):Ro 08-2750 inhibits the survival of human AML lines and patient cells. Ro 08-2750 suppresses MSI2 RNA-binding and alters the MSI2 gene signature. Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore. Ro 08-2750 (5-10 μM; 8?hours) increases differentiation and apoptosis in myeloid leukemia cells. Ro 08-2750 (10 nM) fully rescues cells from undergoing NGF-induced SK-N-MC 103 cell death .(In Vivo):In a myeloid leukemia model in vivo, Ro 08-2750 (13.75?mg/kg; i.p.) suppresses leukemogenesis .
  • In Vitro
    Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore.Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.Ro 08-2750 (5-10 μM; 8?hours) increases differentiation and apoptosis in myeloid leukemia cells.Ro 08-2750 inhibits survival of human AML lines and patient cells.Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature. Apoptosis Analysis Cell Line:MLL-AF9?+?BM cells Concentration:5?μM, 10?μM Incubation Time:8?hours Result:Increased apoptosis.
  • In Vivo
    Ro 08-2750 (13.75mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo. Animal Model:C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model Dosage:13.75?mg/kg Administration:Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug)Result:Inhibited c-MYC levels and reduced disease burden.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AhR| Androgen Receptor| Antifungal| Estrogen Receptor/ERR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    37854-59-4
  • Formula Weight
    270.248
  • Molecular Formula
    C13H10N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 4 mg/mL (14.80 mM)
  • SMILES
    Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu J, et al. Whole transcriptome analysis of Penicillium digitatum strains treatmented with prochloraz reveals their drug-resistant mechanisms. BMC Genomics. 2015 Oct 24;16:855.
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