
Ro 08-2750
CAS No. 37854-59-4
Ro 08-2750( —— )
Catalog No. M26808 CAS No. 37854-59-4
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM.
Purity : >98% (HPLC)






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10MG | 87 | Get Quote |
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Biological Information
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Product NameRo 08-2750
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NoteResearch use only, not for human use.
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Brief DescriptionRo 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM.
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DescriptionRo 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA.(In Vitro):Ro 08-2750 inhibits the survival of human AML lines and patient cells. Ro 08-2750 suppresses MSI2 RNA-binding and alters the MSI2 gene signature. Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore. Ro 08-2750 (5-10 μM; 8?hours) increases differentiation and apoptosis in myeloid leukemia cells. Ro 08-2750 (10 nM) fully rescues cells from undergoing NGF-induced SK-N-MC 103 cell death .(In Vivo):In a myeloid leukemia model in vivo, Ro 08-2750 (13.75?mg/kg; i.p.) suppresses leukemogenesis .
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In VitroRo 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore.Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.Ro 08-2750 (5-10 μM; 8?hours) increases differentiation and apoptosis in myeloid leukemia cells.Ro 08-2750 inhibits survival of human AML lines and patient cells.Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature. Apoptosis Analysis Cell Line:MLL-AF9?+?BM cells Concentration:5?μM, 10?μM Incubation Time:8?hours Result:Increased apoptosis.
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In VivoRo 08-2750 (13.75mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo. Animal Model:C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model Dosage:13.75?mg/kg Administration:Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug)Result:Inhibited c-MYC levels and reduced disease burden.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAhR| Androgen Receptor| Antifungal| Estrogen Receptor/ERR
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Research Area——
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Indication——
Chemical Information
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CAS Number37854-59-4
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Formula Weight270.248
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Molecular FormulaC13H10N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 4 mg/mL (14.80 mM)
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SMILESCc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Liu J, et al. Whole transcriptome analysis of Penicillium digitatum strains treatmented with prochloraz reveals their drug-resistant mechanisms. BMC Genomics. 2015 Oct 24;16:855.
molnova catalog



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